The local climatic effect of heterogeneous underlying surface was simulated through the MM5V3 meso-scale model. The simulations reappear the some typical characteristics of the oasis-desert interaction such as mountain valley wind, "oasis effect" in the summer, and "inverse humidity" on desert and oasis-desert vertical circulation which are caused by the thermodynamic distinctions of different underlying surfaces and reveal the physical mechanicsm of the interaction between the land surface and wind field, temperature and humidity in atmospheric boundary layer over heterogeneous land surface. Namely, the results of the numerical simulations in the paper have well tested the ones in field experiments.