The level of nitrogen oxides（NOx）emission is a key indicator for assessing anthropogenic atmospheric pollutant emissions. Understanding the long-term trends of NOx emissions and identifying emission hotspots are of significant importance for air pollution control. This study utilized OMI and TROPOMI data to analyze the long-term trends and spatial distribution characteristics of tropospheric NO2 column density across various regions of Sichuan and Chongqing from 2010 to 2021. Additionally，ground-based NO2 concentration data from environmental monitoring stations and NOx emission data from the MEIC inventory were integrated to evaluate the long-term trends of NOx emissions observed by satellite. Ground-based NO2 concentration measurements and ME‐ IC NO x emission inventory data are incorporated to assess the accuracy of satellite observations. The results show that：（1）The spatial distribution of NO2 column density in the Sichuan-Chongqing region reveals two hotspot areas，including Chengdu and the central urban area of Chongqing. Compared to OMI satellite，TROPOMI，with its higher signal-to-noise ratio and resolution，captures more detailed spatial distribution features；（2）tropo‐ spheric NO2 column density exhibits a declining trend，with rates of -0. 115×1015，-0. 096×1015 and -0. 053×1015 molec·（cm2·a）-1 in the Chengdu Plain，Chongqing，and the Sichuan-Chongqing region，respectively；（3）NO2 column density increased with rising NOx emissions from industrial and transportation sources during 2010 -2012. For the period of 2012 -2015，NO2 column density decreased by 19. 91% across the SichuanChongqing region，which is mainly attributed to substantial emission reductions in power and industrial sectors. From 2015 to 2017，NO2 concentrations increased by 10. 76%，followed by a gradual decline；（4）The trends in satellite-observed NO 2 column density closely align with ground-level ambient NO2 measurements；（5）NO2 column density exhibits distinct seasonal variations：in the Sichuan Basin，winter NO2 concentrations are significantly higher than in other seasons，followed by spring and autumn，with summer concentrations being the low‐ est. In contrast，in the western Sichuan Plateau，NO2 concentrations are higher in summer than in winter due to natural sources.