Climate comfort is a key determinant of human-settlement suitability，tourism development，public health，and climate-adaptation strategies，as its variations directly influence residents’quality of life，tourists’ travel decisions，and the formulation of regional climate resilience policies. Guizhou Province，situated in the eastern Yunnan-Guizhou Plateau，is characterized by complex terrain and varied landforms. This distinctive envi‐ ronment has led to significant temporal and spatial variations in climate comfort across the province，making it a typical region for exploring climate suitability on plateaus. This study systematically analyzed the spatiotemporal distribution patterns of climate comfort across the province’s nine cities and prefectures using the AHP-CRITIC （analytic hierarchy process-criteria importance through intercriteria correlation）method. The research was based on long-term observational data from 84 national meteorological stations spanning three decades（1994-2023）， ensuring a comprehensive and reliable data foundation. A notable advantage of the AHP-CRITIC method lies in its ability to integrate subjective and objective assessment dimensions：it combines the subjective weights of me‐ teorological elements determined by the AHP method with the objective weights derived from the CRITIC meth‐ od. This dual-weight fusion effectively mitigates the limitations of single-method biases，thereby significantly en‐ hancing the scientific rigor of the climate comfort evaluation. Guizhou’s annual climate comfort index showed a declining trend at a rate of -0. 03 per decade，which was primarily driven by a pronounced downward trend in summer，with the rate reaching -0. 11 per decade. In terms of comfortable days，the annual average number of “comfortable”days across the province is 160，among which Liupanshui City stands out with 203“comfortable” days. Liupanshui，Anshun，and Qianxinan each recorded over 300 days annually classified as“relatively com‐ fortable”or better. Specifically，Liupanshui had over 20“comfortable”days per month from April to October， whereas Qianxinan remained“relatively comfortable”or better year-round. Spatially，climate comfort in Gui‐ zhou showed marked seasonal and regional variations，with uniformly high levels across all cities and prefectures in spring and autumn. In summer，Liupanshui，Bijie，Anshun，Guiyang，and the northwest part of Qianxinan maintained“relatively comfortable”to“comfortable”conditions，offering a distinct cool-summer advantage. In winter，most areas were in“relatively uncomfortable”or“uncomfortable”categories except the southern part of the province，with January being the least comfortable month. Contribution decomposition showed air tempera‐ ture to be the dominant driver in every season（contribution rate 47. 5%~63. 8%），followed by wind speed. These findings provide new quantitative insights into climate comfort across the Yunnan-Guizhou Plateau and serve as a reference for understanding the spatiotemporal distribution and variations of climate comfort in Gui‐ zhou under climate change scenarios.